'To not be' or 'not to be'
I don't think so, but I am no grammar expert. Hamlet Act 3, Scene 1 Famous Shakespeare Quote Although set in different times many of the most famous quotes about life and love by William Shakespeare are still relevant today. Established drugs tested were mitotane, cisplatin, etoposide, 5-fluorouracil, and suramin. Other agents studied included adenine arabinofuranoside, cytosine arabinofuranoside, 2-methoxyestradiol, and paclitaxel. However, it is difficult to determine off-target effects of editing due to single nucleotide polymorphism in individuals. Genome editing holds promise for correcting pathogenic mutations. But for this, the joyful hope of this, Who'd bear the scorns and flattery of the world, Scorned by the right rich, the rich cursed of the poor? God was at first pleased with his creation, then later felt grieved and regretted his creation. In order to do this, one must reproduce so beauty will live. Likewise, suppositions, views, claims, and assertions can be wrong. To die: to sleep; No more; and by a sleep to say we end The heart-ache and the thousand natural shocks That flesh is heir to, 'tis a consummation Devoutly to be wish'd. But I suggest that it is amazing that he did not even try any alternative before opting for death. It's very hard to not think about the future. Adam asks in particular about to not seek and not to take, but nearly any combination of infinitive and not would be possible. In the above example, to boldly go seems more urgent and may convey exactly the right idea to others. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Among the nonplanar conformations of the pyrimidine rings, the boat-like and half-chair conformations are the most populated. Never mind wondering how a god outside time does anything at all. Much of the plot of 1942 sophisticated comedy , by , is focused on the monologue of Hamlet; in 1957 comedy film , recites the famous monologue in the shoes of the ambiguous king Shahdov. The rest of the soliloquy goes on to use a number of metaphors. So one may argue that He is either a sadistic voyeur in many specific cases, or is not all powerful. Actually, the question has to do with where to put to and not when using the infinitive form of any verb. In the first quatrain, Shakespeare begins his meditation on the process of decay. To die, to sleep, perchance to Dream; aye, there's the rub, For in that sleep of death, what dreams may come, When we have shuffled off this mortal coil, Must give us pause. However, since the presuppositions in questions are often implicit, it is easy not to notice the wrongness of some of the questions we ask. I can think of a couple of things in the bible that seem to suggest the biblical god is not omniscient. If I inquire about the cause of cancer, I presuppose that there is such a disease and that it has a cause. This residue, C27, was disordered in the previously determined three-dimensional structure of the complex, suggesting that it is dynamic in solution. The presupposed component of a question may be correct or incorrect. What inspired Shakespeare to create any of his famous works? Adrenocortical carcinoma is an uncommon malignancy that is usually fatal within a short time after diagnosis. In 1608, Susanna Shakespeare and John Hall had their first Gustafson 3 child: a daughter named Elizabeth Hall William 1028 Words 5 Pages Racquel Marsh Prof. Of course, we'd escape a lot by being dead, like being spurned in love. Free will is a poorly defined idea to begin with. The widow being oppressed, the orphan wrong'd, The taste of hunger, or a tyrants reign, And thousand more calamities besides, To grunt and sweat under this weary life, When that he may his full Quietus make, With a bare bodkin, who would this endure, But for a hope of something after death? One cannot have a will if one has no desire. Susanna Shakespeare married a Stratford doctor named John Hall. Certainly, if anyone is asked to quote a line of Shakespeare this is the one that first comes to mind for most people. To die though, action in life is needed, making the proposition circular and hopeless. One can lessen significantly or even discontinue one's overall suffering in various ways, such as dealing with the causes of suffering, moving away from them, making oneself less sensitive to suffering, dealing with one's tendencies, or compensating for the suffering there is in life by creating and augmenting joyful or worthy aspects of life. Let us know in the comments below. It's like comparing apples and oranges. Yet, the insertion of a centrally located M opposite any canonical base in a duplex is sometimes even less destabilizing than that of some mismatches, and the variation in duplex stability is small. The difficulties in measuring the charge transport in a single molecule through direct contact is often exacerbated in the cases of biomolecules due to the effects of environment that change drastically between experimental conditions which cause differences in the configuration of the molecule and the local interference effects. To be, or not to be, that is the question: Whether 'tis nobler in the mind to suffer The slings and arrows of outrageous fortune, Or to take Arms against a Sea of troubles, And by opposing end them: to die, to sleep; No more; and by a sleep, to say we end The heart-ache, and the thousand natural shocks That Flesh is heir to? Widespread application of gene therapy will depend on the development of simple methods to regulate the expression of therapeutic genes. Which puzzles the brain, and doth confound the sense, Which makes us rather bear those evils we have, Than fly to others that we know not of. So it's not a false dichotomy. We propose new ideas for storing data, which are based on currently developed technologies and out-of-the-box thinking. It turns out that the real rule is a question of clarity and style and not grammar. I think the only way a believer could claim they had free will would be if they also claimed that their god is not omniscient. Death is something desirable — devoutly to be wished, a consummation — a perfect closure. Claims state that there is no evidence to document William Shakespeare of Stratford as the author and that he did not have the aristocratic background, education, or knowledge to have 934 Words 4 Pages beautiful people. And since every action requires a prior thought, there you go. Inhibition of p53 prevents the damage response and increases the rate of homologous recombination from a donor template. When questions are based on wrong presuppositions, the questions are wrong. The addition of Adenine A -Thymine T base-pairs causes an exponential decrease in the conductance, suggesting a tunneling mechanism. Likewise, if I asked why you hate me, I would wrongly presuppose that you hate me. We're born with these desires which we initially try to satisfy until we learn how to be a part of society. And while you do that, I'll just return the compliment by asserting that all atheists are simply maladjusted individuals who, due to bad circumstances in life, can't seem to find room for faith in God in their own hearts and minds. The strand can be folded onto itself, i. Thus, M is non-discriminating and none-too-destabilizing in a duplex, but in a triplex it is extremely destabilizing when in the third strand. Claiming that a question is wrong may sound odd. Shakespeare in his 12th sonnet talks about his experience and fading beauty. The only catch is that we might have dreams when dead—bad dreams. I have recently talked with new parents of a 3-month-old baby. Plus Hamlet feels betrayed by his mom because she married so soon after his dad's death. This is quite different from an ex-situ Nafion-Fe bpy 32+ complex system that showed unstable response at neutral pH. Looking forward to your comments. The question is still valid, and a choice to make. We must also struggle in our lives because those before us made the same struggle and certainly we should therefore also struggle to make our lives worthy of their efforts! Reprinted as The First Edition of the Tragedy of Hamlet: London, 1603. The weaker bonding of the adenine molecule with the gold surface is unable to prevent the voltage induced reconstruction of the Au 110 surface. Soft you now, The faire Ophelia, Nimph in thy orizons Be all my ſinnes remembred. Hamlet was composed not as a text for reading but as a text for playing, and each individual actor chooses how the text will be phrased and delivered, without regard to the feeble devices of literary editors. However, if there is also not something presupposed, on which we base the question, again there would be no questioning. We suffer all for the faint glimpse of hope and that makes for such a long life for who would hold on without hope? But his suicide also shook the Austro-Hungarian Empire. It is a very understandable, very human limitation. How it is punctuated is more important than what marks S, Q2, or F1 used. He's saying being in love is like being hit with thousands of arrows because it hurts so much. Often, people think of suicide when they are in a crisis. ¹² reduces adenine base editor off-target activity in human cells. We're all just born how we are, a process that is more or less random. And life after death is an unknown, possibly worse than life itself. There is a direct opposition — to be, or not to be. Note that I am not claiming here that it is certain that Rudolf would have found the first alternative way of living he would have tried out as sufficiently good. Shakespeare shows us how some love is eternal and will live on forever in comparison to a beautiful summer's day. Christian members please remember to read the Statement of Purpose threads for each forum within Christian Congregations before posting in the forum. But that's pretty much the point of this speech. Here we harness an endogenous signaling pathway to regulate therapeutic gene expression through diet. For one thread used, speed up is about 4. It is not even necessarily an accurate observer or depictor of life. Death is empowering, allowing the defeat of fortune. Allhem, Malmö American-Scandinavian Foundation, New York, 1967. God asks satan what he has been up to which again does not suggest omniscience. To be, or not to be, Ay there's the point, To Die, to sleep, is that all? Hamlet's dilemma is that although he is dissatisfied with life and lists its many torments, he is unsure what death may bring the dread of something after death. The question being, do Christians consider the biblical god to be omniscient or do they consider him not to be omniscient? He can't be sure what death has in store; it may be sleep but in 'perchance to dream' he is speculating that it is perhaps an experience worse than life. This was not the type of life he wanted. Thus conscience does make cowards of us all; And thus the native hue of resolution Is sicklied o'er with the pale cast of thought, And enterprises of great pith and moment With this regard their currents turn awry, And lose the name of action. We expect too much of ourselves. Rudolf chose to commit suicide rather than to continue living like that. Dust to Dust Dust to dust , Earth to earth The simple and the noble birth Will shed their skin and leave their kin Despite their given worth The perfect body and the lame The smart, the wealthy and insane, Will crumble to a little heap Of molecules, the same The farm, the precious jewels , the cars The castles with the golden spas Will leave thy face, yet stay in place And pass and pass and pass Tomorrow and the living day Reflections of but yesterday Entwined upon our minds like weeds Unwelcomed yes, but chose to stay. So how do we know what to expect when we die? Job is then put to the test to show his loyalty to the biblical god and it would appear that satan did not consider god to be omniscient as only a complete fool would bet against a being it knew was omniscient and therefore in full knowledge of the outcome of such a wager. This means that Anne Hathaway would be approximately eight years older than William Shakespeare, making Anne Hathaway about twenty-six at the time she and William Shakespeare got married. Death, too, however, is a big change. For example, if I ask you what the time now is, I presuppose in this question, among other things, that you have a watch, that you know to read time, and that there is such a thing as time. This is an excellent example one of many of why I cannot subscribe to the popular notion that art and literature teach the reader valuable life lessons. That was a third option, besides either suffering or suicide. Death is called the undiscover'd country from which no traveller returns. Otherwise you'd have to posit that creation is an on going activity which kind of makes God limited. Yet Rudolf didn't try even one option. Nymph, in thy Orisons Be all my sins remember'd. Thus conscience does make cowards of us all, And thus the native hue of resolution Is sicklied o'er with the pale cast of thought, And enterprises of great pith and moment With this regard their currents turn awry And lose the name of action. To cut a long story short, Dr. You can't use this example by Shakespeare as an example of using 'not'. And to his dad's murderer no less. Future promises even commercially available methods for storing and reading information. Our system may be particularly well suited for intermittent regulation of therapeutic transgenes over short or long time periods. Even if we did choose them, that would still solve nothing. Moreover, if I found my present way of living unbearable, and an alternative one would have also been unsatisfactory, I surely would have tried out several other alternatives as well; perhaps if things did not turn out well in the first option they would have turned out quite well in a second or third try. For who would bear the whips and scorns of time, Th'oppressor's wrong, the proud man's contumely, The pangs of dispriz'd love, the law's delay, The insolence of office, and the spurns That patient merit of th'unworthy takes, When he himself might his quietus make With a bare bodkin? Nimph, in thy Orizons Be all my ſinnes remembred. To be, or not to be, that is the question What's the meaning of the phrase 'To be or not to be, that is the question'? Death is therefore empowering: killing oneself is a way of taking action, taking up arms, opposing and defeating the slings and arrows of outrageous fortune. With that thought, Hamlet stops to reconsider. In this soliloquy, he compares death to a little sleep, which he thinks wouldn't be so bad. In fact, questions can be wrong in several ways. However, the absence of thermally-induced hyperchromic changes by single-stranded deoxyoligomers in which M alternates with A or C residues shows that M does not stack strongly with A or C nearest neighbors. However, his father and social conventions disallowed a and to a woman he did love, and who loved him back, Marie Vetsera. In addition, he married Anne Hathaway, 26, when he turned 18, having 3 children, Hamnet, Judith and Susanna. Hamlet now seems to make a decision. These data suggest that paclitaxel, 2-methoxyestradiol, and cytosine arabinofuranoside should be further evaluated for their potential in the chemotherapy of adrenal carcinoma. I also have great difficulty in understanding why a supposedly omniscient being and creator of mankind would do so knowing that even before the creation started that he would eventually destroy his creation, that his creation would vex him and fill him with regret even though he was initially pleased with his creation. Please review our current list for information on which faith groups are considered to be Christian faiths. Aye all: No, to sleep, to dream, aye marry there it goes, For in that dream of death, when we awake, And borne before an everlasting Judge, From whence no passenger ever returned, The undiscovered country, at whose sight The happy smile, and the accursed damn'd. Landau's words are the best at showing an otherwise depressed person that all is not lost - better days ahead. This leads him to all the troubles and tragic errors he makes Lear has to be the first play with dementia as its theme. Hamlet now lets his imagination wander on the subject of the voyages of discovery and the exploratory expeditions. It is called Kronborg Castle and is in the Danish port of Helsingør. With the partial exception of the Sonnets 1609 , quarried since the early 19th century for autobiographical secrets allegedly encoded in them, the nondramatic writings have traditionally been pushed. What do I care if He's Almighty or All-knowing or not? Many Christians would say he is. We are slaves to our desire, and no, Christ doesn't set you free from that. When it comes down to it, he's talking about you, us, and everyone else out there. In the speech, Hamlet contemplates death and , bemoaning the pain and unfairness of life but acknowledging that the alternative might be worse. In fact, the only thing I can be certain of is that I will never be certain about what God is or can do, and I say this with truncated or superficial interpretations of notwithstanding. We must push it out of our minds, seek help, take drugs and get therapy. It has been calculated that a performance begins somewhere in the world every minute of every day. Many targeted base transversions, insertions, and deletions remain challenging due to the lack of precise and efficient genome editing technologies. Throughout his childhood, he went to the performances in his town and was heavily influenced by Catholicism. In this monologue and the yorrich monologue he is clearly depressed, suicidal and confused. Its the dilemma of accepting or refuting a pregnancy. However, what inspired Shakespeare to write such a play? However, Hamlet is unsure of what course of action he wants to take to exact his revenge. Also, it means that he didn't create all of the universe in an instant just part of it--a time-slice of it. These episodes involved learning about and fighting the artificial intelligence species. Even in a highly religionised society he managed to write his numerous plays without mentioning the Bible once. Thus conscience does make cowards of us all, And thus the native hue of resolution Is sicklied o'er with the pale cast of thought, And enterprises of great pitch and moment With this regard their currents turn awry And lose the name of action. Hamlet starts with him seeing ghosts and hearing voices that implore him to murder. In saying that Hamlet is acknowledging that, not only does each living person discover death for themselves, as no one can return from it to describe it, but also that suicide is a one-way ticket. But there is more to it than that. Who would bear that when he could just draw a line under life with something as simple as a knitting needle — a bodkin? Hardly the reactions you would attribute to an omniscient being. We thereby enabled discrimination of neighboring C nucleotides, which would otherwise be edited with similar efficiency, and doubled the number of disease-associated target Cs able to be corrected preferentially over nearby non-target Cs. To be, or not to be: that is the question: Whether 'tis nobler in the mind to suffer The slings and arrows of outrageous fortune, Or to take arms against a sea of troubles, And by opposing end them. Defining speed up as the ratio of the time taken to run the original serial program on one thread to the time taken to run the tiled program on P threads, we achieve super-linear speed up a value of speed up is greater than the number of threads used for parallel tiled code against the original serial code up to 32 threads and super-linear speed up scalability increasing speed up with increasing the thread number up to 8 threads. Who would theſe Fardles beare To grunt and ſweat vnder a weary life, But that the dread of ſomething after death, The vndiſcouered Countrey, from whoſe Borne No Traueller returnes, Puzels the will, And makes vs rather beare those illes we haue, Then flye to others that we know not of. Getting our questions right is very important, since wrong questions lead to wrong replies. We have these primitive desires, desires which are fundamental to us and which we cannot control. I far prefer to read literature for the layman on scientific research than fiction or even biographies - such as this article! In Shakespeare's Hamlet, too, there are more options than either to kill oneself or to continue to suffer. If there were not something unknown, about which we inquire, there would be no questioning; we would have nothing to ask about. A significant reduction of costs of this type of coding is needed. The forums in the Christian Congregations category are now open only to Christian members. Comparison of the whole genome sequences of progeny cells of edited vs. Of course, doing this would have shaken the Austro-Hungarian Empire. But it is also a wrong understanding of this problem. To die, to sleep; To sleep: perchance to dream: ay, there's the rub; For in that sleep of death what dreams may come When we have shuffled off this mortal coil, Must give us pause: there's the respect That makes calamity of so long life; For who would bear the whips and scorns of time, The oppressor's wrong, the proud man's contumely, The pangs of despised love, the law's delay, The insolence of office and the spurns That patient merit of the unworthy takes, When he himself might his quietus make With a bare bodkin? The balance continues with a consideration of the way one deals with life and death. That is hardly the reaction of a supposedly omniscient being and it also calls into question the claim that the biblical god does not change. Living is a passive state; dying is an active state. For example, Rudolf could have left the court with his beloved Marie, traveled somewhere, learned a profession, worked, and lived with and loved Marie. Shakespeare's line 'to be or not to be' is usually interpreted as meaning 'is it better to live or to die'? The Tragedie of Hamlet, Prince of Denmarke in Mr. Hamlet is thinking about life and death and pondering a state of being versus a state of not being — being alive and being dead. It is impossible to know whose pointing and orthography either represents: Shakespeare's, a copyist's, Heminges and Condell's, or the printers'. It presents only two alternatives to choose from when, in fact, there are more. At the end of the soliloquy, he pulls himself out of this reflective mode by deciding that too much thinking about it is the thing that will prevent the action he has to rise to. Not only answers, views, and claims, then, can be wrong; questions can be wrong as well. Yet his suicide also caused much sorrow to his parents. Thus conſcience dooes make cowards, And thus the natiue hiew of reſolution Is ſickled ore with the pale caſt of thought, And enterpriſes of great pitch and moment, With this regard theyr currents turne awry, And loose the name of action. If God created everything, he created the space-time continuum. It indicates that the so-called B10. We are not allowed to contemplate suicide today. He and Marie Vetsera noted only the two options Hamlet recites: continuing life as it is, or dying. Either way, the two self-evident options are 'to be' and 'not to be,' and 'not choosing either' is not so much another option, as much as it is the choice of not choosing any option. At the time of marriage, William Shakespeare and Anne Hathaway were already expecting their first child, Susanna Shakespeare. What will happen when we have discarded all the hustle and bustle of life? Generated parallel tiled code is scalable regarding to the number of parallel threads — increasing the number of threads reduces code execution time. Hamlet is really seriously considering those Big Questions about life and death, and what it means to live. I try not to think about how hard I'll have to work. A few years later, in 1585, William Shakespeare and Anne Hathaway had twins: a daughter named Judith Shakespeare and a son named Hamnet Shakespeare. Moving to, say, France, learning a trade, and working would have surely been a big change. Adenine base editors ¹ enable efficient targeted adenine-to-guanine single nucleotide conversions to induce or correct point mutations in human cells, animals, and plants 1—4. Aye that, O this conscience makes cowards of us all, Lady in thy orizons, be all my sins remembered. Whereas, the addition of Guanine G -Cytosine C base-pairs shows a weak algebraic dependence on the conductance suggesting a hopping mechanism. Throughout the action of the play, he makes excuses for not killing him and turns away when he has the chance. But, when the target duplex opposition is M-T and the third strand residue is T, the presence of M in the test triplet has little effect on triplex stability. One decreases suffering by improving life rather than destroying it. Add to this the fact that Shakespeare is dealing with profound concepts, putting complex philosophical ideas into the mouth of a character on a stage and communicating with an audience with a wide range of educational levels, and you have a selection of reasons as to why this soliloquy is as famous as it is. For example, a fourth option that is sometimes useful is just to wait. These complementary strands are built of basic building block called bases. To die: to sleep; No more; and by a sleep to say we end The heart-ache, and the thousand natural shocks That flesh is heir to, 'tis a consummation Devoutly to be wish'd. This is not entirely a moment of possible suicide. The soliloquy presupposes Shakespeare's Montaigne-esque take on the human condition, which includes pervasive anguish to some extent, whether greater or lesser. Rather, consider this whole process as a huge and extremely complicated Rube-Goldberg-Maschine. Leaving the court would have also caused much sorrow to his parents. I personally never contemplated suicide, but have always looked for a way above any sad predicaments. Soft you now, The faire Ophelia? The only two texts with any authority, Q2 and F1, point this differently: Q2: To be, or not to be, that is the question, F1: To be, or not to be, that is the Question: The relative authority of Q2 and F1 has been hotly debated for centuries, mostly with respect to the fairly long passages unique to each. His thoughts about that develop in the rest of the soliloquy. When his plays were not published until after his death, some questions were raised about whether Shakespeare was the one who really wrote them.。 。 。 。 。
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